Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …

The successful clinical application of nucleic acid-based therapeutic strategies has been
limited by the poor delivery efficiency achieved by existing vectors. The development of …

Nonviral gene complexes can enter mammalian cells through different endocytic pathways.
For efficient optimization of the gene carrier it is important to profile its cellular uptake …

Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to
translocate across biological membranes in a non-disruptive way and to overcome the …

The clinical use of efficient therapeutic agents is often limited by the poor permeability of the
biological membranes. In order to enhance their cell delivery, short amphipathic peptides …

Short regulatory oligonucleotides (ONs) have a great therapeutic potential for the
modulation of gene expression due to their high specificity and low toxicity. The major …

Understanding the mechanisms responsible for carbon nanotube (CNT) internalisation into
live cells is considered critical both from a fundamental point of view and for further …

Abstract Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often
specifically termed as “the Trojan horse approach”, has become the “holy grail” in achieving …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in
high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs …

Trp is unique among the amino acids since it is involved in many different types of
noncovalent interactions such as electrostatic and hydrophobic ones, but also in π-π, π …