Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with …

A Arjunan, DK Sah, M Woo, J Song - Cell & Bioscience, 2023 - Springer
Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Organ abnormalities caused by Turner syndrome

SH Yoon, GY Kim, GT Choi, JT Do - Cells, 2023 - mdpi.com
Turner syndrome (TS), a genetic disorder due to incomplete dosage compensation of X-
linked genes, affects multiple organ systems, leading to hypogonadotropic hypogonadism …

Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease

D Sepúlveda, F Grunenwald, A Vidal… - Scientific Reports, 2022 - nature.com
Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as
biomolecules of interest related to idiopathic Parkinson's disease (PD). The objective of this …

Is insulin-like growth factor-1 involved in Parkinson's disease development?

I Castilla-Cortázar, GA Aguirre, G Femat-Roldán… - Journal of translational …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …

Parkinson's disease and sugar intake—reasons for and consequences of a still unclear craving

J Haas, D Berg, A Bosy-Westphal, E Schaeffer - Nutrients, 2022 - mdpi.com
Lately, studies have shown that patients with Parkinson's disease (PD) report a strong
craving for sweets and consume significantly more fast-acting carbohydrates than healthy …

Promising biomarkers and therapeutic targets for the management of Parkinson's disease: recent advancements and contemporary research

MA Khan, N Haider, T Singh, R Bandopadhyay… - Metabolic Brain …, 2023 - Springer
Parkinson's disease (PD) is one of the progressive neurological diseases which affect
around 10 million population worldwide. The clinical manifestation of motor symptoms in PD …

[HTML][HTML] The molecular mechanisms of the relationship between insulin resistance and Parkinson's disease pathogenesis

VA Ruiz-Pozo, R Tamayo-Trujillo, S Cadena-Ullauri… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a degenerative condition resulting from the loss of dopaminergic
neurons. This neuronal loss leads to motor and non-motor neurological symptoms. Most PD …

Assessing white matter pathology in early-stage Parkinson disease using diffusion MRI: a systematic review

M Bergamino, EG Keeling, VR Mishra… - Frontiers in …, 2020 - frontiersin.org
Structural brain white matter (WM) changes such as axonal caliber, density, myelination, and
orientation, along with WM-dependent structural connectivity, may be impacted early in …

Insulin-like growth factor-1 differentially modulates glutamate-induced toxicity and stress in cells of the neurogliovascular unit

CA Hayes, BG Ashmore, A Vijayasankar… - Frontiers in Aging …, 2021 - frontiersin.org
The age-related reduction in circulating levels of insulin-like growth factor-1 (IGF-1) is
associated with increased risk of stroke and neurodegenerative diseases in advanced age …

Evolving Landscape of Parkinson's Disease Research: Challenges and Perspectives

R Tenchov, JM Sasso, QA Zhou - ACS omega, 2025 - ACS Publications
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
movement. It occurs due to a gradual deficit of dopamine-producing brain cells, particularly …