Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …

Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

Transition metals, such as iron, copper, and zinc, play a very important role in life as the
regulators of various physiochemical reactions in cells. Abnormal distribution and …

Zinc dyshomeostasis has been recognized as an important mechanism for cell death in
acute brain injury. An increase in the level of free or histochemically reactive zinc in …

Metals can have a number of detrimental or beneficial effects in the cell, but first they must
get in. Organisms have evolved transport mechanisms to get metals that are required, or …

Protein misfolding and conformational changes are a cornerstone of neurodegenerative
diseases involving formation and deposition of toxic protein oligomers. Although mutations …