Dietary carbohydrates and fats in nonalcoholic fatty liver disease

H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

Childhood obesity and the associated rise in cardiometabolic complications

S Caprio, N Santoro, R Weiss - Nature metabolism, 2020 - nature.com
Childhood obesity is one of the most serious global public-health challenges of the twenty-
first century. Over the past four decades, the number of children and adolescents with …

Adipose tissue development and expansion from the womb to adolescence: an overview

CE Orsso, E Colin-Ramirez, CJ Field, KL Madsen… - Nutrients, 2020 - mdpi.com
Prevalence rates of pediatric obesity continue to rise worldwide. Adipose tissue (AT)
development and expansion initiate in the fetus and extend throughout the lifespan. This …

100th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism

AC Carpentier - American Journal of Physiology …, 2021 - journals.physiology.org
Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …

Increased adipose tissue fibrogenesis, not impaired expandability, is associated with nonalcoholic fatty liver disease

JW Beals, GI Smith, M Shankaran, A Fuchs… - …, 2021 - Wiley Online Library
Background and Aims It is proposed that impaired expansion of subcutaneous adipose
tissue (SAT) and an increase in adipose tissue (AT) fibrosis causes ectopic lipid …

Tracers and imaging of fatty acid and energy metabolism of human adipose tissues

AC Carpentier - Physiology, 2024 - journals.physiology.org
White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid
metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic …

Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease

I Palacios-Marin, D Serra, J Jimenez-Chillarón… - Nutrients, 2023 - mdpi.com
The alarming increase in obesity and its related metabolic health complications, such as
type 2 diabetes, has evolved into a global pandemic. Obesity is mainly characterized by …

Alterations in adipose tissue distribution, cell morphology, and function mark primary insulin hypersecretion in youth with obesity

D Tricò, M Chiriacò, J Nouws, A Vash-Margita… - Diabetes, 2024 - Am Diabetes Assoc
Excessive insulin secretion independent of insulin resistance, defined as primary
hypersecretion, is associated with obesity and an unfavorable metabolic phenotype. We …

Benefits of physical activity on cardiometabolic diseases in obese children and adolescents

J Gao, Y Lu, P Gokulnath, G Vulugundam… - Journal of …, 2022 - degruyter.com
In the past few decades, obesity in the pediatric population has dramatically increased and
is common in many countries. Childhood obesity often causes health problems and …

An evolutionary model for the ancient origins of polycystic ovary syndrome

DA Dumesic, DH Abbott, GD Chazenbalk - Journal of Clinical Medicine, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged
women, characterized by hyperandrogenism, oligo-anovulation and insulin resistance and …