Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

The maintenance of machinery requires its operational understanding and a toolbox for
repair. The methods for the precision engineering of native proteins meet a similar …

Efficient and site‐specific modification of native peptides and proteins is desirable for
synthesizing antibody‐drug conjugates as well as for constructing chemically modified …

Bioactive peptides are widely used in functional foods due to their remarkable efficacy,
selectivity, and low toxicity. However, commercially produced bioactive peptides lack quality …

Chemical cross-linking of proteins coupled with mass spectrometry is widely used in protein
structural analysis. In this study we develop a class of non-hydrolyzable amine-selective di …

Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds
for the discovery of therapeutics and development of chemical probes. Aided by the …

Peptide modification methods that do not rely on the cysteine residue are underdeveloped,
and their development could greatly expand the current toolbox for peptide chemistry …

Radical thiol-ene chemistry has been demonstrated for a range of applications in peptide
science, including macrocyclization, glycosylation and lipidation amongst a myriad of others …

Easy access to a wide range of structurally diverse stapled peptides is crucial for the
development of inhibitors of protein‐protein interactions. Herein, we report bis‐functional …