This review covers the last 80 years of remarkable progress in the development of
mineralocorticoid receptor (MR) antagonists (MRAs) from synthesis of the first …

Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and
current therapies that limit CKD progression and the development of cardiovascular disease …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Based on global estimates, almost 10% of adults have diabetes, of whom 40% are estimated
to also have chronic kidney disease (CKD). Almost 2 decades ago, treatments targeting the …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

Chronic kidney disease (CKD) represents a global health concern, and its prevalence is
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …

The hyperphagia, low sympathetic nervous system tone, and decreased circulating
concentrations of bioactive thyroid hormones that are common to states of congenital leptin …

Acute kidney injury induced by ischemia/reperfusion is an independent risk factor for chronic
kidney disease. Macrophage recruitment plays an essential role during the injury and repair …

Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …