Nephrotoxicity is a common adverse effect of the clinically used polymyxins, colistin and
polymyxin B. This adverse effect is dose limiting for both polymyxins, as the plasma …

Biofilms are sessile communities of bacteria typically embedded in an extracellular
polymeric matrix. Bacterial cells embedded in biofilms are inherently recalcitrant to …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Background. Polymyxin B is a last-line therapy for multidrug-resistant gram-negative
bacteria. There is a dearth of pharmacokinetic data to guide dosing in critically ill patients …

The continuing emergence of multi-drug resistant pathogens has sparked an interest in
seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such …

Antibiotic therapy is the routine method for treating bacterial infections and has saved
hundreds of millions of lives over the last century. However, low bioavailability, side effects …

To better understand the difficulties surrounding the identification of novel antibacterial
compounds from corporate screening collections, physical properties of∼ 3200 antibacterial …

Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-
negative bacteria; however, nephrotoxicity associated with these drugs is a very common …

Despite concerns of nephrotoxicity, polymyxin antibiotics often remain the only susceptible
agents for multidrug-resistant (MDR) Gram-negative bacteria. Colistin has been more …

Antimicrobial peptides are small, cationic proteins that can induce lysis of bacterial cells
through interaction with their membranes. Different mechanisms for cell lysis have been …