The majority of bone cell biology focuses on activity on the surface of the bone with little
attention paid to the activity that occurs below the surface. However, with recent new …

Tissue engineering is a rapidly evolving discipline that seeks to repair, replace, or
regenerate specific tissues or organs by translating fundamental knowledge in physics …

Much recent evidence suggests that bone cells sense their mechanical environment via
interstitial fluid flow. In this review, we summarize theoretical and experimental approaches …

Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …

This contribution reviews recent research performed to assess the porosity and permeability
of bone tissue with the objective of understanding interstitial fluid movement. Bone tissue …

Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which
orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet …

There are two main types of fluid in bone tissue, blood and interstitial fluid. The chemical
composition of these fluids varies with time and location in bone. Blood arrives through the …

CONTEXT: Lower bone density in young amenorrheic athletes (AA) compared to
eumenorrheic athletes (EA) and non-athletes may increase fracture risk during a critical time …

While interstitial fluid flow is necessary for the viability of osteocytes, it is also believed to
play a role in bone's mechanosensory system by shearing bone cell membranes or causing …

Bone represents a porous tissue containing a fluid phase, a solid matrix, and cells.
Movement of the fluid phase within the pores or spaces of the solid matrix translates …