Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …

Cellular proteostasis requires transport of polypeptides across membranes. Although
defective transport processes trigger cytosolic rescue and quality control mechanisms that …

Efficient movement of proteins across membranes is required for cell health. The
translocation process is particularly challenging when the channel in the membrane through …

The human kinome comprises 538 kinases playing essential functions by catalyzing protein
phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

Oxidative phosphorylation (OXPHOS) is the mechanism whereby ATP, the major energy
source for the cell, is produced by harnessing cellular respiration in the mitochondrion. This …

Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria
by protein translocases. Yet, mitochondria contain their own genome and gene expression …