In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …

Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved,
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …

Activation of the Akt/protein kinase B (PKB) kinase pathway can be neuroprotective after
stroke. Akt is activated by growth factors via a phosphorylation-dependent pathway involving …

Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds
(CMBs) are considered various manifestations of cerebral small vessel disease (SVD) …

Cerebral ischemia triggers robust phosphorylation of cAMP response element‐binding
protein (CREB) and CRE‐mediated gene expression in neurons. Glutamate receptor …

Phosphodiesterase (PDE) is a superfamily of enzymes that are responsible for the
hydrolysis of two second messengers: cyclic adenosine monophosphate (cAMP) and cyclic …

The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10)
is a lipid and protein phosphatase. We report here that PTEN physically associates with the …

Depressive disorder is the most prevalent affective disorder today. Depressive disorder has
been linked to changes in the white matter. White matter changes in depressive disorder …

Cerebral ischemia/reperfusion (I/R) injury-induced neuronal apoptosis contributes to the
death and disability in patients with ischemic stroke. However, underlying mechanisms …

Myocardial ischaemia/reperfusion injury leading to myocardial infarction is one of the most
frequent causes of debilitation and death in man. Considerable research has been …