The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Abstract Sirtuin1 (SIRT1) is a conserved nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylase that plays key roles in a range of cellular events, including …

Abstract Sirtuins (SIRTs) are NAD+-dependent histone deacetylases, which play a key role
in cancer progression; however, their prognostic values in breast cancer (BC) remain a …

Breast cancer (BC) is the most prevalent type of cancer in women worldwide and it is
classified into a few distinct molecular subtypes based on the expression of growth factor …

Background Triple negative breast cancer (TNBC) is a strongly proliferative, relapse prone,
high-mortality subtype of breast cancer. Due to the lack of effective therapeutic targets, the …

Isobolographic analysis of interactions – a pre-clinical perspective Page 1 www.jpccr.eu CASE
STUDY Isobolographic analysis of interactions – a pre-clinical perspective Jarogniew J …

Aim: Breast cancer remains a significant cause of mortality worldwide, necessitating the
development of innovative therapeutic approaches. Epigenetic and epitranscriptomic …