Cisplatin nephrotoxicity: a review of the literature
Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It
remains an important and effective therapy in many forms of cancer today. Cisplatin …
remains an important and effective therapy in many forms of cancer today. Cisplatin …
Mechanisms of cisplatin nephrotoxicity
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …
Drug-induced acute kidney injury
MA Perazella, MH Rosner - … Journal of the American Society of …, 2022 - journals.lww.com
Medications are a common cause of AKI, especially for patients admitted to hospital wards
and the intensive care unit. Although drug-related kidney injury occurs through different …
and the intensive care unit. Although drug-related kidney injury occurs through different …
Comparative adverse effect profiles of platinum drugs
MJ McKeage - Drug safety, 1995 - Springer
Since the discovery of the biologically active platinum complexes 30 years ago, 2 agents
have become widely established in clinical oncology practice. Both cisplatin and carboplatin …
have become widely established in clinical oncology practice. Both cisplatin and carboplatin …
Weekly high-dose cisplatin is a feasible treatment option: analysis on prognostic factors for toxicity in 400 patients
FE De Jongh, RN Van Veen, SJ Veltman… - British journal of …, 2003 - nature.com
In the present study we describe the toxicity of weekly high-dose (70–85 mg m− 2) cisplatin
in 400 patients (203 men, 197 women; median age 54 years) with advanced solid tumours …
in 400 patients (203 men, 197 women; median age 54 years) with advanced solid tumours …
Cisplatin-induced renal toxicity in elderly people
ZY Duan, GY Cai, JJ Li… - Therapeutic advances in …, 2020 - journals.sagepub.com
Despite available prevention and treatment measures, such as hydration, diuresis,
magnesium supplementation, and amifostine, renal toxicity is still one of the major dose …
magnesium supplementation, and amifostine, renal toxicity is still one of the major dose …
International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency
A SIOG taskforce was formed to discuss best clinical practice for elderly cancer patients with
renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer …
renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer …
Phase Ib/II trial of NC-6004 (nanoparticle cisplatin) plus gemcitabine in patients with advanced solid tumors
V Subbiah, JE Grilley-Olson, AJ Combest… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: NC-6004, a novel cisplatin nanoparticle developed using micellar
technology exhibits sustained release of cisplatin and selective distribution to tumors …
technology exhibits sustained release of cisplatin and selective distribution to tumors …
Estimation of glomerular filtration rate in cancer patients
JG Wright, AV Boddy, M Highley, J Fenwick… - British journal of …, 2001 - nature.com
The frequent need to obtain an estimate of renal function in cancer patients, not least for
targeting carboplatin dose, has led to a number of approaches to estimate glomerular …
targeting carboplatin dose, has led to a number of approaches to estimate glomerular …
Mitochondrial superoxide dismutase in cisplatin-induced kidney injury
Cisplatin is a chemotherapy agent commonly used to treat a wide variety of cancers. Despite
the potential for both severe acute and chronic side effects, it remains a preferred …
the potential for both severe acute and chronic side effects, it remains a preferred …