Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the development of
preventative therapies for AF has been disappointing. The infiltration of immune cells and …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial
fibrosis are poorly understood. The goal of this study was to use patient-derived atrial …

Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart
disease. One of the most frequent and potentially life threatening disorders of DM-induced …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

The long QT syndrome (LQTS), classified as congenital or acquired, is a multi-factorial
disorder of myocardial repolarization predisposing to life-threatening ventricular …

Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world.
Most CVDs are associated with increased inflammation that arises mainly from innate …

Abstract Toll-like receptor 4 (TLR4) is expressed in a wide variety of cells and is the central
component of the mammalian innate immune system. Since its discovery in 1997, TLR4 has …

KV channel-interacting proteins (KChIP1-4) belong to a family of Ca2+-binding EF-hand
proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. KChIPs are …

Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, a better
understanding of their pathomechanisms and the subsequent implementation of optimal …