l, 8-Naphthalimide based DNA intercalators and anticancer agents. A systematic review from 2007 to 2017
MD Tomczyk, KZ Walczak - European journal of medicinal chemistry, 2018 - Elsevier
In this review, we describe a detailed investigation about the structural variations and
relative activity of 1, 8-naphthalimide based intercalators and anticancer agents. The 1, 8 …
relative activity of 1, 8-naphthalimide based intercalators and anticancer agents. The 1, 8 …
Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs
E Baglini, S Salerno, E Barresi, M Robello… - European Journal of …, 2021 - Elsevier
DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …
Heterocyclic naphthalimides as new skeleton structure of compounds with increasingly expanding relational medicinal applications
HH Gong, D Addla, JS Lv… - Current topics in medicinal …, 2016 - ingentaconnect.com
Naphthalimide compounds are an important type of nitrogen-containing aromatic
heterocycles with cyclic double imides and the naphthalene framework. This π-deficient …
heterocycles with cyclic double imides and the naphthalene framework. This π-deficient …
Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells
Combinatorial inhibition of Topoisomerase 1 (TOP1) and Poly (ADP-ribose) polymerase 1
(PARP1) is an attractive therapeutic strategy which is under active investigation to address …
(PARP1) is an attractive therapeutic strategy which is under active investigation to address …
Design, synthesis and antitumor evaluation of new 1, 8-naphthalimide derivatives targeting nuclear DNA
GB Liang, JH Wei, H Jiang, RZ Huang, JT Qin… - European Journal of …, 2021 - Elsevier
Four series of new 3-nitro naphthalimides derivatives, 4 (4a‒4f), 5 (5a‒5i), 6 (6a‒6e) and 7
(7a‒7j), were designed and synthesized as antitumor agents. Methyl thiazolyl tetrazolium …
(7a‒7j), were designed and synthesized as antitumor agents. Methyl thiazolyl tetrazolium …
Novel potentially antibacterial naphthalimide-derived metronidazoles: Design, synthesis, biological evaluation and supramolecular interactions with DNA, human …
J Kang, VKR Tangadanchu, L Gopala, WW Gao… - Chinese Chemical …, 2017 - Elsevier
A series of novel naphthalimide-derived metronidazoles as new type of antimicrobial agents
were for the first time designed, synthesized and characterized by NMR, IR and HRMS …
were for the first time designed, synthesized and characterized by NMR, IR and HRMS …
Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action
Z Chen, Y Xu, X Qian - Chinese Chemical Letters, 2018 - Elsevier
In this review, we retrospect our progress in biological active naphthalimide and analogues
as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide …
as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide …
Design of a 1, 8-naphthalimide-based OFF-ON type bioorthogonal reagent for fluorescent imaging in live cells
Z Shao, C Zhang, X Zhu, Y Wang, W Xu, Y Chen… - Chinese Chemical …, 2019 - Elsevier
Abstract A novel 1, 8-naphthalimide-based OFF-ON type fluorogenic sydnone (Naph-Syd) is
designed as bioorthogonal probe for imaging. Sydnone moiety efficiently quenches the …
designed as bioorthogonal probe for imaging. Sydnone moiety efficiently quenches the …
Pt (IV) Complexes in the Search for Novel Platinum Prodrugs with Promising Activity
The kinetically inert, six coordinated, octahedral Pt (IV) complexes are termed dual-, triple-,
or multi-action prodrugs based on the nature of the axially substituted ligands. These ligands …
or multi-action prodrugs based on the nature of the axially substituted ligands. These ligands …
Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents
GB Liang, YC Yu, JH Wei, WB Kuang, ZF Chen… - European Journal of …, 2020 - Elsevier
A serial of naphthalenebenzimidizole-Pt complexes 1–6 were designed and synthesized as
antitumor agents. In vitro antitumor assay results showed that complexes 1–6 exhibited …
antitumor agents. In vitro antitumor assay results showed that complexes 1–6 exhibited …