Cardiac hypertrophy, initiated by a variety of physiological or pathological stimuli
(hemodynamic or hormonal stimulation or infarction), is a critical early adaptive …

MG53, a member of the tripartite motif protein family, possesses multiple functionalities due
to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase …

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a
promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily …

Doxorubicin (DOX) is an anthracycline medication that is commonly used to treat solid
tumors. However, DOX has limited clinical efficacy due to known cardiotoxicity. Ferroptosis is …

Aims Heart failure (HF) is a prevalent age‐related cardiovascular disease with poor
prognosis in the elderly population. This study aimed to establish the causal relationship …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …

Oxidative stress plays a crucial role in cadmium (Cd)-induced myocardial injury. Mitsugumin
53 (MG53) and its mediated reperfusion injury salvage kinase (RISK) pathway have been …

Chronic muscle inflammation exacerbates the pathogenesis of Duchenne muscular
dystrophy (DMD), which is characterized by progressive muscle degeneration and …

Kidney fibrosis is associated with the progression of acute kidney injury to chronic kidney
disease. MG53, a cell membrane repair protein, has been shown to protect against injury to …

Pyroptosis, a novel programmed cell death mediated by NOD-like receptor protein 3
(NLRP3) inflammasome, is a critical pathogenic process in acute viral myocarditis (AVMC) …