Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
[HTML][HTML] Type 2 immunity in tissue repair and fibrosis
Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …
immune response is commonly observed in tissues during allergic inflammation or infection …
Metformin reverses established lung fibrosis in a bleomycin model
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs
in a number of organs, including the lungs. Cellular metabolism regulates tissue repair and …
in a number of organs, including the lungs. Cellular metabolism regulates tissue repair and …
Fibroblast heterogeneity: implications for human disease
MD Lynch, FM Watt - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …
in maintaining the structural integrity of most tissues. Researchers have long suspected that …
Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
Y Liu, Y Liu, W He, X Mu, X Wu, J Deng… - Frontiers in …, 2022 - frontiersin.org
Diabetes is a systemic disease in which patients with diabetes may develop peripheral
neuropathy of the lower extremities and peripheral vascular disease due to long-term …
neuropathy of the lower extremities and peripheral vascular disease due to long-term …
Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets
B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …
Correlation of circular RNA abundance with proliferation–exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues
A Bachmayr-Heyda, AT Reiner, K Auer… - Scientific reports, 2015 - nature.com
Circular RNAs are a recently (re-) discovered abundant RNA species with presumed
function as miRNA sponges, thus part of the competing endogenous RNA network. We …
function as miRNA sponges, thus part of the competing endogenous RNA network. We …
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
Pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …
Fibrotic extracellular matrix activates a profibrotic positive feedback loop
MW Parker, D Rossi, M Peterson… - The Journal of …, 2014 - Am Soc Clin Investig
Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …