A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …

Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …

Background White matter hyperintensities of presumed vascular origin (WMH) are one of the
imaging features of cerebral small vessel disease. Controversies persist about the effects of …

White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

Background During the aging process, physical capabilities (eg, muscular strength) and
cognitive functions (eg, memory) gradually decrease. Regarding cognitive functions …

The term cerebral small vessel disease refers to a group of pathological processes with
various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the …

Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …

Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people,
but there are still no curative options. Senile plaques and neurofibrillary tangles are …