Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Lactose malabsorption is a common condition caused by reduced expression or activity of
lactase in the small intestine. In such patients, lactose intolerance is characterized by …

There is increasing evidence that genome-wide association (GWA) studies represent a
powerful approach to the identification of genes involved in common human diseases. We …

The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan …

Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV
consists of a combination of PEGylated interferon-α (PEG-IFN-α) and ribavirin (RBV). To …

A SNP in the gene encoding lactase (LCT)(C/T-13910) is associated with the ability to digest
milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase …

Niche construction is the process by which organisms construct important components of
their local environment in ways that introduce novel selection pressures. Lactase …

Lactase persistence (LP) is common among people of European ancestry, but with the
exception of some African, Middle Eastern and southern Asian groups, is rare or absent …

Most people are born with the ability to digest lactose, the major carbohydrate in milk and
the main source of nutrition until weaning. Approximately 75% of the world's population …

Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …