The role of cancer-specific target antigens in CAR T cell therapy in hematological malignancies

TH Khan, N Muhammad, M Tarique, D Usmani… - Current Tissue …, 2024 - Springer
Abstract Purpose of Review CAR T cell therapy has revolutionized the cancer therapy.
However, for an effective therapy, selecting an ideal target antigen on the cancer cell is a …

B cells in head and neck squamous cell carcinoma: current opinion and novel therapy

X Guo, L Xu, L Nie, C Zhang, Y Liu, R Zhao… - Cancer Cell …, 2024 - Springer
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite
advancements in surgery, radiotherapy and chemotherapy, which have improved the …

HMGB1 in exosomes derived from gastric cancer cells induces M2‐like macrophage polarization by inhibiting the NF‐κB signaling pathway

K Liu, H Wang, J Zhou, S Zhu, M Ma… - Cell Biology …, 2024 - Wiley Online Library
Gastric cancer (GC) seriously threatens human health. High mobility group protein B1
(HMGB1) and M2‐like macrophages are closely associated with core events about human …

Disulfidptosis-related signature predicts prognosis and characterizes the immune microenvironment in hepatocellular carcinoma

J Tang, X Peng, D **ao, S Liu, Y Tao, L Shu - Cancer cell international, 2024 - Springer
Background Disulfidptosis is a type of programmed cell death caused by excessive cysteine-
induced disulfide bond denaturation leading to actin collapse. Liver cancer has a poor …

Current stage of preclinical and clinical development of guggulsterone in cancers: Challenges and promises

S Ijaz, J Iqbal, BA Abbasi, A Tufail… - Cell Biology …, 2024 - Wiley Online Library
Throughout human history, the utilization of medicinal herbs has been recognized as a
crucial defense against various ailments, including cancer. Natural products with potential …

MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3

A Zhao, Y Pan, Y Gao, Z Zhi, H Lu, B Dong, X Zhang… - BMC cancer, 2024 - Springer
In contrast to the decreasing trends in developed countries, the incidence and mortality rates
of cervical squamous cell carcinoma in China have increased significantly. The screening …

The role of ncRNAs and exosomes in the development and progression of endometrial cancer

J Niebora, S Woźniak, D Domagała, K Data… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Endometrial cancer (EC) is one of the most common gynecologic cancers. In recent years,
research has focused on the genetic characteristics of the tumors to detail their prognosis …

LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma

M Rong, M Zhang, F Dong, K Wu, B Cai, J Niu… - Cancer Cell …, 2024 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are key regulators of the 6-
methyladenosine (m6A) epigenetic modification, playing a role in the initiation and …

AML cell‐derived exosomes suppress the activation and cytotoxicity of NK cells in AML via PD‐1/PD‐L1 pathway

D Wang, F Zhou, L He, X Wang, L Song… - Cell Biology …, 2024 - Wiley Online Library
Exosomes are bilayer lipid bodies and contain a variety of bioactive molecules such as
proteins, lipids, and nucleic acids, and so forth. Exosomes derived from solid tumors may …

Mortalin promotes the evolution of androgen-independent prostate cancer through Wnt/β-catenin signaling pathway

Y Chang, J Sui, Q Fu, Z Lu, Z Piao, T **… - Cancer Cell …, 2024 - Springer
Prostate cancer (PC) is a major global health concern affecting male individuals. Among its
variants, androgen-independent prostate cancer exhibits slow progression and lacks …