Targeting SARS-CoV-2 papain-like protease in the postvaccine era

AT Ton, M Pandey, JR Smith, F Ban… - Trends in …, 2022 - cell.com
While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …

Applications of density functional theory in COVID-19 drug modeling

N Ye, Z Yang, Y Liu - Drug discovery today, 2022 - Elsevier
The rapidly evolving Coronavirus 2019 (COVID-19) pandemic has led to millions of deaths
around the world, highlighting the pressing need to develop effective antiviral …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

[HTML][HTML] Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/3CLpro: molecular docking and simulation studies of three pertinent medicinal …

D Verma, D Mitra, M Paul, P Chaudhary… - Current Research in …, 2021 - Elsevier
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and …

HERC5 and the ISGylation pathway: critical modulators of the antiviral immune response

NA Mathieu, E Paparisto, SD Barr, DE Spratt - Viruses, 2021 - mdpi.com
Mammalian cells have developed an elaborate network of immunoproteins that serve to
identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa …

Computational evaluation of quinones of Nigella sativa L. as potential inhibitor of dengue virus NS5 methyltransferase

M Roney, A Dubey, MH Nasir, AM Huq… - Journal of …, 2024 - Taylor & Francis
Aedes aegypti is the primary vector for the transmission of the dengue virus, which causes
dengue fever, dengue hemorrhagic illness and dengue shock syndrome. There is now no …

Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World

MF Rehman, S Akhter, AI Batool, Z Selamoglu… - Antibiotics, 2021 - mdpi.com
The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …

Interactions between SARS coronavirus 2 papain‐like protease and immune system: a potential drug target for the treatment of COVID‐19

S Mahmoudvand, S Shokri - Scandinavian journal of …, 2021 - Wiley Online Library
Coronaviruses (CoVs) are a large family of respiratory viruses which can cause mild to
moderate upper respiratory tract infections. Recently, new coronavirus named as Severe …

In Silico Elucidation of Potent Inhibitors and Rational Drug Design against SARS-CoV-2 Papain-like Protease

K Sanachai, P Mahalapbutr… - The Journal of …, 2021 - ACS Publications
Global public health has been a critical problem by the sudden increase of the COVID-19
outbreak. The papain-like protease (PLpro) of SARS-CoV-2 is a key promising target for …

Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies

S Mousavi, S Zare, M Mirzaei… - Canadian Journal of …, 2022 - Wiley Online Library
Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease
outbreak, there has been an increasing interest in discovering potential therapeutic agents …