Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Abstract The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

OBJECTIVE: To summarize the role of melatonin in the physiology and pathophysiology of
the ovary. DESIGN: Review of literature. SETTING: University Health Science Center …

The purpose of this systematic review is to access the current state of knowledge concerning
the role for melatonin in human pregnancy. Melatonin is a neuroendocrine hormone …

Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and
derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some …

The production of the pineal hormone melatonin is synchronized with day-night cycle via
multisynaptic pathway including suprachiasmatic nucleus linking several physiological …

The pineal hormone melatonin, an important regulator of circadian and seasonal rhythms,
has a role in ocular pathophysiology. In addition to the pineal gland, melatonin synthesis is …

Many biological processes display circadian rhythms in activity, which presumably operate
to coordinate cellular functions with daily environmental oscillations. The diurnal changes in …

Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR
subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The …