Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

HER2 is an established therapeutic target in a large subset of women with breast cancer; a
variety of agents including trastuzumab, pertuzumab, lapatinib, neratinib and trastuzumab …

BACKGROUND In contrast to lung cancer, few precision treatments are available for
colorectal cancer (CRC). One rapidly emerging treatment target in CRC is ERBB2 (human …

Colorectal cancer (CRC) is the most common gastrointestinal malignancy in the USA and
approximately 50% of patients develop metastatic disease (mCRC). Despite our …

Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

Tumor sidedness has emerged as an important prognostic and predictive factor in the
treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right …

MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene
involved in embryonic development and throughout life in homeostasis and tissue …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death attributed
to high frequency of metastasis and multiple drug resistance. We aim to examine the …

Microtubules are multifunctional cytoskeletal proteins that are involved in crucial cellular
roles including maintenance of cell shape, intracellular transport, meiosis, and mitosis. Class …

The conclusion derived from the information provided in this review is that disseminating
tumor cells (DTC) collaborate with the microenvironment of a future metastatic organ site in …