Brain insulin resistance: role in neurodegenerative disease and potential for targeting

C Hölscher - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction: This review evaluates the novel strategy of treating Alzheimer's and Parkinson's
disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes …

NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in type 2 diabetes mellitus: a narrative review and new perspective

M Alrouji, HM Al‐kuraishy, AI Al‐Gareeb… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). Genetic predisposition and immune dysfunction are involved in …

[HTML][HTML] Promising use of metformin in treating neurological disorders: biomarker-guided therapies

A Loan, C Syal, M Lui, L He, J Wang - Neural Regeneration …, 2024 - journals.lww.com
Neurological disorders are a diverse group of conditions that affect the nervous system and
include neurodegenerative diseases (Alzheimer's disease, multiple sclerosis, Parkinson's …

Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease

M Naoi, W Maruyama, M Shamoto-Nagai… - Journal of Neural …, 2024 - Springer
Parkinson's disease is characterized by its distinct pathological features; loss of dopamine
neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy …

Challenges of repurposing tetracyclines for the treatment of Alzheimer's and Parkinson's disease

I Markulin, M Matasin, VE Turk… - Journal of neural …, 2022 - Springer
The novel antibiotic-exploiting strategy in the treatment of Alzheimer's (AD) and Parkinson's
(PD) disease has emerged as a potential breakthrough in the field. The research in animal …

Modeling of Parkinson's disease by intrastriatal administration of streptozotocin

JO Barilar, V Papic, V Farkas, I Rubic, P Meglic… - …, 2025 - Elsevier
Parkinson's disease (PD) is a highly heterogeneous and therefore a possible cause of
translation failure of drugs from animal testing to human treatments can be because existing …

Persistence and severity of cutaneous manifestations in IgA vasculitis is associated with development of IgA vasculitis nephritis in children

M Sestan, S Srsen, N Kifer, M Sapina… - Dermatology, 2022 - karger.com
Abstract Background/Objective: The purpose of this study was to evaluate the prevalence
and severity of skin involvement in children with IgA vasculitis (IgAV) and its relationship with …

Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose …

J Homolak, A Babic Perhoc, A Knezovic… - …, 2022 - karger.com
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …

Additional methodological considerations regarding optimization of the dose of intracerebroventricular streptozotocin A response to:“Optimization of …

J Homolak, AB Perhoc, A Knezovic… - Metabolic brain …, 2021 - Springer
A recent article by Ghosh et al. entitled" Optimization of intracerebroventricular
streptozotocin dose for the induction of neuroinflammation and memory impairments in rats" …

Association of cognitive deficit with glutamate and insulin signaling in a rat model of Parkinson's disease

A Knezovic, M Piknjac, J Osmanovic Barilar… - Biomedicines, 2023 - mdpi.com
Cognitive deficit is a frequent non-motor symptom in Parkinson's disease (PD) with an
unclear pathogenesis. Recent research indicates possible involvement of insulin resistance …