Experimental and CFD physical characterization of animal cell bioreactors: from micro-to production scale

TK Villiger, B Neunstoecklin, DJ Karst, E Lucas… - Biochemical …, 2018 - Elsevier
Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is
a delicate task, frequently leading to different conditions across scales. To provide a more …

Experimental and modeling study of breakage and restructuring of open and dense colloidal aggregates

YM Harshe, M Lattuada, M Soos - Langmuir, 2011 - ACS Publications
In this work we present experimental and simulation analysis of the breakage and
restructuring of colloidal aggregates in dilute conditions under shear. In order to cover a …

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture

B Neunstoecklin, M Stettler, T Solacroup, H Broly… - Journal of …, 2015 - Elsevier
Application of quality by design (QbD) requires identification of the maximum operating
range for parameters affecting the cell culture process. These include hydrodynamic stress …

Shear-induced breakup of cellulose nanocrystal aggregates

HN Xu, YY Tang, XK Ouyang - Langmuir, 2017 - ACS Publications
The flow properties of two kinds of cellulose nanocrystal (CNC) rods with different aspect
ratios and similar zeta potentials in aqueous suspensions have been investigated. The …

Response of shear‐activated nanotherapeutic particles in a clot‐obstructed blood vessel by CFD‐DEM simulations

L Vasquez Giuliano, A Buffo, M Vanni… - … Canadian Journal of …, 2022 - Wiley Online Library
In recent years, targeted drug delivery systems have been regarded as a promising solution
to enhance the efficiency of treatments against clots in blood vessels. In this context, shear …

Breakage rate of colloidal aggregates in shear flow through Stokesian dynamics

YM Harshe, M Lattuada - Langmuir, 2012 - ACS Publications
We study the first breakage event of colloidal aggregates exposed to shear flow by detailed
numerical analysis of the process. We have formulated a model, which uses Stokesian …

Temperature influence on MBS latex aggregate morphology

A Hamieh, C Coufort-Saudejaud, A Couffin… - Colloids and Surfaces A …, 2023 - Elsevier
This paper aims to better understand the impact of process conditions on the morphological
properties of MBS (Methacrylate Butadiene Styrene) core-shell latex aggregates during an …

Generation and geometrical analysis of dense clusters with variable fractal dimension

L Ehrl, M Soos, M Lattuada - The Journal of Physical Chemistry B, 2009 - ACS Publications
The generation and geometrical analysis of clusters composed of rigid monodisperse
primary particles with variable fractal dimension, df, in the range from 2.2 to 3 are presented …

Revealing Crystal Aggregates' Evolution through In Situ Visualization in Cooling Crystallization

Y **ao, Z Pan, H Wang, T Li, B Kong - Industrial & Engineering …, 2024 - ACS Publications
The transition process and control mechanisms of crystal aggregates to agglomerates hold
significant importance in reducing subsequent processing steps and enhancing crystal …

Texture, transport and mechanical properties of graphite nanoplatelet/silicone composites produced by three roll mill

MA Raza, AVK Westwood, AP Brown… - Composites science and …, 2012 - Elsevier
Thermally conducting and highly compliant composites for thermal interface applications
were developed by dispersing graphite nanoplatelets (GNPs) in silicone polymer using a …