Metallodrugs in medicinal inorganic chemistry

KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives

I Yousuf, M Bashir, F Arjmand, S Tabassum - Coordination Chemistry …, 2021 - Elsevier
Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

Prospective of 68Ga-radiopharmaceutical development

I Velikyan - Theranostics, 2013 - pmc.ncbi.nlm.nih.gov
Positron Emission Tomography (PET) experienced accelerated development and has
become an established method for medical research and clinical routine diagnostics on …

Clinical applications of Gallium-68

SR Banerjee, MG Pomper - Applied Radiation and Isotopes, 2013 - Elsevier
Gallium-68 is a positron-emitting radioisotope that is produced from a 68Ge/68Ga generator.
As such it is conveniently used, decoupling radiopharmacies from the need for a cyclotron …

Scandium and terbium radionuclides for radiotheranostics: current state of development towards clinical application

C Müller, KA Domnanich, CA Umbricht… - The British journal of …, 2018 - academic.oup.com
Currently, different radiometals are in use for imaging and therapy in nuclear medicine:
68Ga and 111In are examples of nuclides for positron emission tomography (PET) and …

[HTML][HTML] Somatostatin receptor PET ligands-the next generation for clinical practice

E Pauwels, F Cleeren, G Bormans… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using
radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be …

[HTML][HTML] THERANOSTICS: from molecular imaging using Ga-68 labeled tracers and PET/CT to personalized radionuclide therapy-the Bad Berka experience

RP Baum, HR Kulkarni - Theranostics, 2012 - ncbi.nlm.nih.gov
The acronym THERANOSTICS epitomizes the inseparability of diagnosis and therapy, the
pillars of medicine and takes into account personalized management of disease for a …

The Beginning and Development of the Theranostic Approach in Nuclear Medicine, as Exemplified by the Radionuclide Pair 86Y and 90Y

F Rösch, H Herzog, SM Qaim - Pharmaceuticals, 2017 - mdpi.com
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a
therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the …

Past, present and future of 68Ge/68Ga generators

F Rösch - Applied Radiation and Isotopes, 2013 - Elsevier
68Ga represents one of the very early radionuclides applied to positron emission
tomography (PET) imaging at a time when even the wording PET itself was not established …