Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …

Neuroblastoma (NB) is an aggressive pediatric tumor, responsible for 15% of cancer-related
deaths in childhood, lacking an effective treatment in its advanced stages. The P2X7 …

The past decades of biomedical research have yielded massive evidence for the
contribution of the microbiome in the development of a variety of chronic human diseases …

P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular
influx of Na+ and Ca 2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its …

Acute myeloid leukemia (AML) is a common adult leukemia often arising from a preexistent
myelodysplastic syndrome (MDS). High mortality rates of AML are caused by relapse and …

P2X7 is an intriguing ionotropic receptor for which the activation by extracellular ATP
induces rapid inward cationic currents and intracellular signalling pathways associated with …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …

The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral
development and progression both in solid cancers and hematological malignancies. The …