RNAi-based therapeutics and tumor targeted delivery in cancer

G Kara, GA Calin, B Ozpolat - Advanced drug delivery reviews, 2022 - Elsevier
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Polymeric micelles and cancer therapy: An ingenious multimodal tumor-targeted drug delivery system

SK Hari, A Gauba, N Shrivastava, RM Tripathi… - Drug Delivery and …, 2023 - Springer
Since the beginning of pharmaceutical research, drug delivery methods have been an
integral part of it. Polymeric micelles (PMs) have emerged as multifunctional nanoparticles in …

Polymeric nanocarriers of drug delivery systems in cancer therapy

N Avramović, B Mandić, A Savić-Radojević, T Simić - Pharmaceutics, 2020 - mdpi.com
Conventional chemotherapy is the most common therapeutic method for treating cancer by
the application of small toxic molecules thatinteract with DNA and causecell death …

Recent advances in develo** polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

J Kaur, M Gulati, NK Jha, J Disouza, V Patravale… - Drug Discovery …, 2022 - Elsevier
Polymeric micelles (PMs) have been explored pre-clinically for the delivery of
chemotherapeutics to treat cancer. Their unique features, such as easy surface …

Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications

AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …

Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer

T Ahmadzada, G Reid, DR McKenzie - Biophysical reviews, 2018 - Springer
Gene silencing via RNA interference (RNAi) is rapidly evolving as a personalized approach
to cancer treatment. The effector molecules—small interfering RNAs (siRNAs) and …

Efficient nanocarriers of siRNA therapeutics for cancer treatment

MA Subhan, VP Torchilin - Translational Research, 2019 - Elsevier
Nanocarriers as drug delivery systems are promising and becoming popular, especially for
cancer treatment. In addition to improving the pharmacokinetics of poorly soluble …

siRNA based drug design, quality, delivery and clinical translation

MA Subhan, VP Torchilin - Nanomedicine: Nanotechnology, Biology and …, 2020 - Elsevier
Gene silencing by RNA interference represents a promising therapeutic approach. The
development of carriers, eg, polymers, lipids, peptides, antibodies, aptamers, small …

Biodegradable polymers for gene delivery

TJ Thomas, HA Tajmir-Riahi, CKS Pillai - Molecules, 2019 - mdpi.com
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers

JD Torres-Vanegas, JC Cruz, LH Reyes - Pharmaceutics, 2021 - mdpi.com
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …