RAS‐targeted cancer therapy: Advances in drugging specific mutations
C Liu, D Ye, H Yang, X Chen, Z Su, X Li, M Ding… - MedComm, 2023 - Wiley Online Library
Rat sarcoma (RAS), as a frequently mutated oncogene, has been studied as an attractive
target for treating RAS‐driven cancers for over four decades. However, it is until the recent …
target for treating RAS‐driven cancers for over four decades. However, it is until the recent …
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors
J Brands, S Bravo, L Jürgenliemke, L Grätz… - Nature …, 2024 - nature.com
A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides
by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive …
by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive …
[HTML][HTML] Biomolecular NMR in the AI-assisted structural biology era: Old tricks and new opportunities
Over the last 40 years nuclear magnetic resonance (NMR) spectroscopy has established
itself as one of the most versatile techniques for the characterization of biomolecules …
itself as one of the most versatile techniques for the characterization of biomolecules …
Balancing G protein selectivity and efficacy in the adenosine A2A receptor
The adenosine A2A receptor (A2AR) engages several G proteins, notably Go and its
cognate Gs protein. This coupling promiscuity is facilitated by a dynamic ensemble, revealed …
cognate Gs protein. This coupling promiscuity is facilitated by a dynamic ensemble, revealed …
Next-generation tags for fluorine nuclear magnetic resonance: designing amplification of chemical shift sensitivity
Fluorine NMR is a highly sensitive technique for delineating the conformational states of
biomolecules and has shown great utility in drug screening and in understanding protein …
biomolecules and has shown great utility in drug screening and in understanding protein …
Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes
Opioid receptors, a subfamily of G protein-coupled receptors (GPCRs), are key therapeutic
targets. In the canonical GPCR activation model, agonist binding is required for receptor–G …
targets. In the canonical GPCR activation model, agonist binding is required for receptor–G …
Photoaging Decoded: Extracellular Matrix Alterations and Mechanisms via Mitogen-Activated Protein Kinase/Matrix Metalloproteinase, Transforming Growth Factor-β …
E Liu, Z Xue, Y Li, Y Liao - Tissue Engineering Part B: Reviews, 2024 - liebertpub.com
Photoaged skin features an appearance of premature aging induced by external factors,
mainly ultraviolet (UV) irradiation. Visible aging signs and increased susceptibility to skin …
mainly ultraviolet (UV) irradiation. Visible aging signs and increased susceptibility to skin …
Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates
The tools of structural biology have undergone remarkable advances in the past decade.
These include new computational and experimental approaches that have enabled studies …
These include new computational and experimental approaches that have enabled studies …
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery
G protein-coupled receptors (GPCRs) are the largest human membrane protein family that
transduce extracellular signals into cellular responses. They are major pharmacological …
transduce extracellular signals into cellular responses. They are major pharmacological …
Nanodiscs for the study of membrane proteins
Nanodiscs represent a versatile tool for studies of membrane proteins and protein-
membrane interactions under native-like conditions. Multiple variations of the Nanodisc …
membrane interactions under native-like conditions. Multiple variations of the Nanodisc …