Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic
instability results from mutations in DNA repair genes and drives cancer development, as …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …

The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes.
We have identified a clue to the mechanistic origins of aneuploidy through integrative …

In contrast to normal cells, aneuploidy—alterations in the number of chromosomes—is
consistently observed in virtually all cancers. A growing body of evidence suggests that …

Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a
family history of the disease, and major genes causing syndromes predisposing to CRC only …