Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …

Diffuse gliomas are among the most common adult central nervous system tumors with an
annual incidence of more than 16,000 cases in the United States. Until very recently, the …

Summary The histone H3 K27M mutation has been frequently reported in most diffuse
midline gliomas. However, the relationship between the H3 K27M mutation and clinical …

Background “Diffuse midline glioma (DMG), H3 K27M-mutant” is a new tumor entity
established in the 2016 WHO classification of Tumors of the Central Nervous System that …

Background: H3 K27M mutation was originally described in pediatric diffuse intrinsic pontine
gliomas (DIPGs), but has been recently recognized to occur also in adult midline diffuse …

The fifth edition of the World Health Organization (WHO) classification of central nervous
system tumors published in 2021 advances the role of molecular diagnostics in the …

Infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) commonly
harbors the classic ETV6-NTRK3 translocation. However, there are recent reports of …

H3 K27‐altered diffuse midline glioma is a highly lethal pediatric‐type tumor without
efficacious treatments. Recent findings have highlighted the heterogeneity among diffuse …

OBJECTIVE H3 K27M-mutant gliomas present heterogeneously in terms of pathology,
imaging, and prognosis. This study aimed to summarize the imaging characteristics of adult …

Pediatric high-grade gliomas (pHGGs) encompass a heterogeneous group of tumors. Three
main molecular types (H3. 3 mutant, IDH mutant, and H3. 3/IDH wild-type) and a number of …