Vaccines and broadly neutralizing antibodies for HIV-1 prevention
Development of improved approaches for HIV-1 prevention will likely be required for a
durable end to the global AIDS pandemic. Recent advances in preclinical studies and early …
durable end to the global AIDS pandemic. Recent advances in preclinical studies and early …
Drug resistance mutations in HIV: new bioinformatics approaches and challenges
Highlights•Machine learning is increasingly used to predict and understand drug resistance
in HIV.•Phylogenetics helps to track the emergence and spread of HIV drug resistance …
in HIV.•Phylogenetics helps to track the emergence and spread of HIV drug resistance …
Pretreatment and acquired antiretroviral drug resistance among persons living with HIV in four African countries
Background Emerging HIV drug resistance (HIVDR) could jeopardize the success of
standardized HIV management protocols in resource-limited settings. We characterized …
standardized HIV management protocols in resource-limited settings. We characterized …
[HTML][HTML] Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis
Objective: To estimate the prevalence of NRTI and NNRTI drug resistance mutations in
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
Clinical outcomes after first‐line HIV treatment failure in South Africa: the next cascade of care
Introduction There is limited literature on the appropriateness of viral load (VL) monitoring
and management of detectable VL in public health settings in rural South Africa. Methods …
and management of detectable VL in public health settings in rural South Africa. Methods …
[HTML][HTML] Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort
L Yue, R Xu, S Mclnally, Q Qin, JW Rhodes, E Muok… - Viruses, 2024 - mdpi.com
HIV-1 subtypes have distinct geographical distributions, with subtypes A, C, and D and inter-
subtype recombinants circulating in sub-Saharan Africa. Historically, individuals living with …
subtype recombinants circulating in sub-Saharan Africa. Historically, individuals living with …
Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study
Background Rising resistance of HIV-1 to non-nucleoside reverse transcriptase inhibitors
(NNRTIs) threatens the success of the global scale-up of antiretroviral therapy (ART). The …
(NNRTIs) threatens the success of the global scale-up of antiretroviral therapy (ART). The …
Increased frequency of inter-subtype HIV-1 recombinants identified by near full-length virus sequencing in Rwandan acute transmission cohorts
G Umviligihozo, E Muok, E Nyirimihigo Gisa… - Frontiers in …, 2021 - frontiersin.org
Most studies of HIV-1 transmission have focused on subtypes B and C. In this study, we
determined the genomic sequences of the transmitted founder (TF) viruses from acutely …
determined the genomic sequences of the transmitted founder (TF) viruses from acutely …
Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link
Background: Considering the remaining threat of drug-resistantmutations (DRMs) to
antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human …
antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human …
Predicting emergent Dolutegravir resistance in South Africa: A modelling study
T Loosli, A Hauser, J Josi, N Han, SM Ingle… - medRxiv, 2024 - medrxiv.org
Background: In response to the rising prevalence of non-nucleoside reverse transcriptase
inhibitors (NNRTIs) resistance, millions of people living with HIV (PWH) have switched to …
inhibitors (NNRTIs) resistance, millions of people living with HIV (PWH) have switched to …