Highlights•Tumor tissues stiffen in disease, but cancer cells can soften.•Some cancer cell
types lose aspects of stiffness sensing.•Ras, FAK and PI3K/Akt signaling have been …

The muscle extracellular matrix (ECM) forms a complex network of collagens, proteoglycans,
and other proteins that produce a favorable environment for muscle regeneration, protect the …

Systemic deletion of senescent cells leads to robust improvements in cognitive,
cardiovascular, and whole‐body metabolism, but their role in tissue reparative processes is …

Musculoskeletal disorders contribute substantially to worldwide disability. Anterior cruciate
ligament (ACL) tears result in unresolved muscle weakness and posttraumatic osteoarthritis …

The production of force and power are inherent properties of skeletal muscle, and regulated
by contractile proteins within muscle fibers. However, skeletal muscle integrity and function …

Key points The amount of fibrotic material in dystrophic mouse muscles relates to contractile
function, but not passive function. Collagen fibres in skeletal muscle are associated with …

As the primary producer of extracellular matrix (ECM) proteins in skeletal muscle, fibroblasts
play an important role providing structural support to muscle. Skeletal muscle ECM is vital for …

Successful muscle regeneration relies on the interplay of multiple cell populations. However,
the signals required for this coordinated intercellular crosstalk remain largely unknown …

Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal
muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix …

Introduction: Assessment of muscle mechanical properties may provide clinically valuable
information for follow‐up of patients with Duchenne muscular dystrophy (DMD) through the …