Cancer remains a main public health issue and the second cause of mortality worldwide.
Photodynamic therapy is a clinically approved therapeutic option. Effective photodynamic …

Clozapine is commonly used to treat schizophrenia but it is having issues of low oral
bioavailability (< 27%), degradation in GI environment and high hepatic first-pass …

The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME)
of drugs, thus knowing this value is critical in drug development. In this review, pKa values …

Felodipine is a calcium channel blocker, which shows low oral bioavailability (< 15%) owing
to poor water solubility and high first pass metabolism. The aim of the present investigation …

Drug distribution is a necessary component of models to predict human pharmacokinetics. A
new membrane-based tissue-plasma partition coefficient (K p) method (K p, mem) to predict …

The solute–solvent interactions of four anticancer drugs, daunorubicin, doxorubicin,
vincristine sulfate, and 6-thioguanine, have been studied in acetonitrile–water mixtures up to …

Materials and Methods: From the perspective of dosage form design and pharmaceutical
analysis, the dissociation constant and partition coefficient are the most important …

We report herein the physicochemical properties and antimicrobial activity of a new
monobrominated derivative of Azure B and its parent compound. These dyes are used as …

This research focused on the precipitation of amorphous forms of nilotinib with high physical
stability through the manipulation of various parameters in the neutralization reaction …

Tirapazamine (3-amino-1, 2, 4-benzotriazine 1, 4-dioxide) is a heterocyclic di-N-oxide that
undergoes enzymatic deoxygenation selectively in the oxygen-poor (hypoxic) cells found in …