Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable,
scalable quantities of disease-relevant tissues from patients suffering from essentially any …

Huntington's disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss
of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell …

Huntington's disease (HD) is a currently incurable and, ultimately, fatal neurodegenerative
disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin …

Conspectus Membrane potential is a fundamental biophysical property maintained by every
cell on earth. In specialized cells like neurons, rapid changes in membrane potential drive …

The promise of cell therapy has been augmented by introducing biomaterials, where
intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we …

Adult-onset neurodegenerative diseases are among the most difficult human health
conditions to model for drug development. Most genetic or toxin-induced cell and animal …

Huntington's disease (HD) is a rare inherited neurodegenerative disease that manifests
mostly in adulthood with progressive cognitive, behavioral, and motor dysfunction. Neuronal …

Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the
huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) …

Movement disorders are neurological conditions in which patients manifest a diverse range
of movement impairments. Distinct structures within the basal ganglia of the brain, an area …