A major advance in antimalarial drug discovery has been the shift towards cell-based
phenotypic screening, with notable progress in the screening of compounds against the …

Although many new anti-infectives have been discovered and developed solely using
phenotypic cellular screening and assay optimization, most researchers recognize that …

Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a
nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary …

Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …

Highlights•Isoprenoid precursors and CoA are essential metabolites generated by
apicoplast-localized enzymes.•Isoprenoids play an essential role in apicoplast …

Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent
drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to …

One of the most powerful approaches to understanding gene function involves turning
genes on and off at will and measuring the impact at the cellular or organismal level. This …

Plasmodium parasites and related pathogens contain an essential nonphotosynthetic
plastid organelle, the apicoplast, derived from secondary endosymbiosis. Intriguingly, a …

Establishing robust genome engineering methods in the malarial parasite, Plasmodium
falciparum, has the potential to substantially improve the efficiency with which we gain …

Malaria continues to be one of the leading causes of human mortality in the world, and the
therapies available are insufficient for eradication. Severe malaria is caused by the …