Physics of muscle contraction
In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …
The Critical Thing about the Ear's Sensory Hair Cells
AJ Hudspeth, P Martin - Journal of Neuroscience, 2024 - jneurosci.org
The capabilities of the human ear are remarkable. We can normally detect acoustic stimuli
down to a threshold sound-pressure level of 0 dB (decibels) at the entrance to the external …
down to a threshold sound-pressure level of 0 dB (decibels) at the entrance to the external …
Quantifying entropy production in active fluctuations of the hair-cell bundle from time irreversibility and uncertainty relations
We introduce lower bounds for the rate of entropy production of an active stochastic process
by quantifying the irreversibility of stochastic traces obtained from mesoscopic degrees of …
by quantifying the irreversibility of stochastic traces obtained from mesoscopic degrees of …
Deiters cells act as mechanical equalizers for outer hair cells
W Zhou, T Jabeen, S Sabha, J Becker… - Journal of …, 2022 - Soc Neuroscience
The outer hair cells in the mammalian cochlea are cellular actuators essential for sensitive
hearing. The geometry and stiffness of the structural scaffold surrounding the outer hair cells …
hearing. The geometry and stiffness of the structural scaffold surrounding the outer hair cells …
Inferring entropy production rate from partially observed Langevin dynamics under coarse-graining
The entropy production rate (EPR) measures time-irreversibility in systems operating far
from equilibrium. The challenge in estimating the EPR for a continuous variable system is …
from equilibrium. The challenge in estimating the EPR for a continuous variable system is …
Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea
M Tobin, A Chaiyasitdhi, V Michel, N Michalski… - Elife, 2019 - elifesciences.org
Sound analysis by the cochlea relies on frequency tuning of mechanosensory hair cells
along a tonotopic axis. To clarify the underlying biophysical mechanism, we have …
along a tonotopic axis. To clarify the underlying biophysical mechanism, we have …
SNARE machinery is optimized for ultrafast fusion
SNARE proteins zipper to form complexes (SNAREpins) that power vesicle fusion with target
membranes in a variety of biological processes. A single SNAREpin takes about 1 s to fuse …
membranes in a variety of biological processes. A single SNAREpin takes about 1 s to fuse …
Control of a hair bundle's mechanosensory function by its mechanical load
Hair cells, the sensory receptors of the internal ear, subserve different functions in various
receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant …
receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant …
Mechanical frequency tuning by sensory hair cells, the receptors and amplifiers of the inner ear
P Martin, AJ Hudspeth - Annual Review of Condensed Matter …, 2021 - annualreviews.org
We recognize sounds by analyzing their frequency content. Different frequency components
evoke distinct mechanical waves that each travel within the hearing organ, or cochlea, to a …
evoke distinct mechanical waves that each travel within the hearing organ, or cochlea, to a …
3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range
In mammals, outer-hair-cell hair bundles (OHBs) transduce sound-induced forces into
receptor currents and are required for the wide dynamic range and high sensitivity of …
receptor currents and are required for the wide dynamic range and high sensitivity of …