Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
Structural basis of a shared antibody response to SARS-CoV-2
Molecular understanding of neutralizing antibody responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and drug …
syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and drug …
Commonality despite exceptional diversity in the baseline human antibody repertoire
In principle, humans can produce an antibody response to any non-self-antigen molecule in
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …
[HTML][HTML] High-throughput map** of B cell receptor sequences to antigen specificity
B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …
infection and vaccination, but it provides limited information about the antigen specificity of …
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …
interventions against COVID-19 disease. However, their common genetic and biologic …
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
Functional antibodies exhibit light chain coherence
The vertebrate adaptive immune system modifies the genome of individual B cells to encode
antibodies that bind particular antigens. In most mammals, antibodies are composed of …
antibodies that bind particular antigens. In most mammals, antibodies are composed of …
[HTML][HTML] Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
Unrelated individuals can produce genetically similar clones of antibodies, known as public
clonotypes, which have been seen in responses to different infectious diseases, as well as …
clonotypes, which have been seen in responses to different infectious diseases, as well as …
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq
B He, S Liu, Y Wang, M Xu, W Cai, J Liu… - Signal transduction and …, 2021 - nature.com
B cell response plays a critical role against SARS-CoV-2 infection. However, little is known
about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire …
about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire …