Enhancing Biocatalysis: Metal–Organic Frameworks as Multifunctional Enzyme Hosts

F Sha, X Wang, KO Kirlikovali… - Accounts of chemical …, 2024 - ACS Publications
Conspectus Enzymes are highly efficient and selective catalysts that operate under mild
conditions, making them invaluable for various chemical transformations. However, their …

Regulating interaction with surface ligands on Au25 nanoclusters by multivariate metal–organic framework hosts for boosting catalysis

H Wang, X Liu, Y Zhao, Z Sun, Y Lin… - National Science …, 2024 - academic.oup.com
While atomically precise metal nanoclusters (NCs) with unique structures and reactivity are
very promising in catalysis, the spatial resistance caused by the surface ligands and …

Machine Learning Optimizing Enzyme/ZIF Biocomposites for Enhanced Encapsulation Efficiency and Bioactivity

W Liang, S Zheng, Y Shu, J Huang - JACS Au, 2024 - ACS Publications
In this study, we present the first example of using a machine learning (ML)-assisted design
strategy to optimize the synthesis formulation of enzyme/ZIFs (zeolitic imidazolate …

Modulating enzyme activity using engineered nanomaterials

A Bhattacharya, S Pandit, S Lee, SB Ebrahimi… - …, 2024 - Wiley Online Library
Enzymes serve as pivotal components in various biotechnological applications across
several industries. Understanding enzyme inhibition sheds light on how certain compounds …

Spatiotemporal Proximity‐Enhanced Biocatalytic Cascades Within Metal–Organic Frameworks for Wearable and Theranostic Applications

L Hao, H Wang, C Liu, Z Wu, J Yi, K Bian… - Advanced …, 2024 - Wiley Online Library
Enzymatic catalysis, particularly multi‐enzyme cascade catalytic, is often limited by the
spatial and temporal separation of enzymes and their signal substrates. Herein, a facile …

Nanoencapsulation of Living Microbial Cells in Porous Covalent Organic Framework Shells

C Li, M Feng, B Li, X Feng, Y Zhang, B Wang - ACS nano, 2025 - ACS Publications
Encapsulating living cells within nanoshells offers an important approach to enhance their
stability against environmental stressors and broaden their application scope. However, this …

Construction of Compartmentalized Meso/Micro Spaces in Hierarchically Porous MOFs with Long-Chain Functional Ligands Inspired by Biological Signal …

Y Tong, J Yang, F **a, J Gu - JACS Au, 2024 - ACS Publications
The creation of spatially coupled meso-/microenvironments with biomimetic
compartmentalized functionalities is of great significance to achieve efficient signal …

A silver cluster-assembled material as a matrix for enzyme immobilization towards a highly efficient biocatalyst

J Sakai, K Sasaki, R Nakatani, S Das, Y Negishi - Nanoscale, 2024 - pubs.rsc.org
Silver cluster-assembled materials (SCAMs) epitomize well-defined extended crystalline
frameworks that combine the ingenious designability at the atomic/molecular level and high …

Amino Functionality Enables Aqueous Synthesis of Carboxylic Acid-Based MOFs at Room Temperature by Biomimetic Crystallization

X Wang, SP Singh, T Zhang, R Andrews… - Inorganic …, 2024 - ACS Publications
Enzyme immobilization within metal–organic frameworks (MOFs) is a promising solution to
avoid denaturation and thereby utilize the desirable properties of enzymes outside of their …

Metal-organic framework-based tunable platform for the immobilization of lipase with enhanced activity in non-aqueous systems

H An, N Gong, H Chen, B **e, Y Zhang… - International Journal of …, 2025 - Elsevier
Nowadays, metal-organic frameworks (MOFs) have been emerged as an efficient platform
for enzyme immobilization due to their high porosity, tunability, and chemical versatility. In …