Drug repurposing for the treatment of bacterial and fungal infections

A Miró-Canturri, R Ayerbe-Algaba… - Frontiers in microbiology, 2019 - frontiersin.org
Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Strategies to combat multidrug-resistant and persistent infectious diseases

O Pacios, L Blasco, I Bleriot, L Fernandez-Garcia… - Antibiotics, 2020 - mdpi.com
Antibiotic failure is one of the most worrying health problems worldwide. We are currently
facing an international crisis with several problematic facets: new antibiotics are no longer …

Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action

E Rizzo - Naunyn-schmiedeberg's Archives of Pharmacology, 2020 - Springer
Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity
towards various infective agents, including viruses. This paper proposes an alternative …

Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

Ivermectin reduces in vivo coronavirus infection in a mouse experimental model

AP Arévalo, R Pagotto, JL Pórfido, H Daghero… - Scientific reports, 2021 - nature.com
The objective of this study was to test the effectiveness of ivermectin for the treatment of
mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2 …

Interplay between ESKAPE pathogens and immunity in skin infections: An overview of the major determinants of virulence and antibiotic resistance

GHR Vale de Macedo, GDE Costa, ER Oliveira… - Pathogens, 2021 - mdpi.com
The skin is the largest organ in the human body, acting as a physical and immunological
barrier against pathogenic microorganisms. The cutaneous lesions constitute a gateway for …

Efficacy and safety of ivermectin for the treatment of COVID-19: a systematic review and meta-analysis

J Deng, F Zhou, S Ali, K Heybati, W Hou… - … Journal of Medicine, 2021 - academic.oup.com
Background Ivermectin became a popular choice for COVID-19 treatment among clinicians
and the public following encouraging results from pre-print trials and in vitro studies. Early …

Ivermectin and mortality in patients with COVID-19: a systematic review, meta-analysis, and meta-regression of randomized controlled trials

AFMZ Zein, CS Sulistiyana, WM Raffaelo… - Diabetes & Metabolic …, 2021 - Elsevier
Aims This systematic review and meta-analysis aims to investigate the effect of ivermectin on
mortality in patients with COVID-19. Methods A comprehensive systematic literature search …

[HTML][HTML] Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices

P Pusparajah, V Letchumanan, JWF Law… - International journal of …, 2021 - mdpi.com
Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent
causes of biomedical device-related infection, which are difficult to treat and are often …

Ivermectin-loaded mesoporous silica and polymeric nanocapsules: Impact on drug loading, in vitro solubility enhancement, and release performance

MC Velho, NL Funk, M Deon, EV Benvenutti… - Pharmaceutics, 2024 - mdpi.com
Ivermectin (IVM), a widely used drug for parasitic infections, faces formulation and
application challenges due to its poor water solubility and limited bioavailability. Pondering …