Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Systematic understanding of immune aging on a whole-body scale is currently lacking. We
characterized age-associated alterations in immune cells across multiple mouse organs …

Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation
of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have …

Background: LncRNA PVT1 has been reported to be involved in a variety of biological
processes, including cell proliferation, cell differentiation and cancer progression. However …

B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal
and malignant B cells. Several lines of evidence support an important pathogenic role of the …

Secondary resistant mutations in cancer cells arise in response to certain small molecule
inhibitors. These mutations inevitably cause recurrence and often progression to a more …

Multiple myeloma (MM) is a haematological B cell malignancy characterised by clonal
proliferation of plasma cells and their accumulation in the bone marrow. The aim of the …

Abstract Prostate apoptosis response-4 (Par-4), a proapoptotic tumor suppressor protein, is
downregulated in many cancers including renal cell carcinoma, glioblastoma, endometrial …

Purpose Neuroblastoma, a common childhood tumor, remains one of the most elusive
diseases to treat. To date, high-risk neuroblastoma is associated with low survival rates. To …