This is the first of two invited articles reviewing the development of nucleoside-analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

At last count, nearly 5000 halogenated natural products have been discovered. In
approximately half of these compounds, the carbon atom to which the halogen is bound is …

Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a
phosphoramidate derivative of 1′-cyano-2′-C-methyl-4-aza-7, 9-dideazaadenosine C …

Covering: 2013 up to the end of 2015 This review covers the isolation and structure of new
pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of …

In the past few decades, our understanding of glycan information‐encoding power has
notably increased, thus leading to a significant growth also in the design and synthesis of …

Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native
folding and impair the trafficking of enzymes, leading to premature endoplasmic reticulum …

C-nucleosides have intrigued biologists and medicinal chemists since their discovery in
1950's. In that regard, C-nucleosides and their synthetic analogues have resulted in …

Glycosidases are key enzymes in metabolism, pathogenic/antipathogenic mechanisms and
normal cellular functions. Recently, a novel approach for glycosidase inhibition that conveys …

Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources.
The interest of the scientific community in these compounds owes itself to their high toxicity …