Over the last four decades, intense research has focused on the effects of small organic
compounds that noncovalently bind to nucleic acids. These interactions have been shown to …

Understanding the thermodynamic and binding characteristics of DNA minor groove binders
(MGBs) is important for the rational design and development of novel MGBs; however, there …

H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and
Mycobacteria, respectively, that play an important role in the silencing of horizontally …

We synthesized a novel anticancer agent MS-247 (2-[[N-[1-methyl-2-[5-[N-[4-[N, N-bis (2-
chloroethyl) amino] phenyl]] carbamoyl]-1 H-benzimidazol-2-yl] pyrrol-4-yl] carbamoyl] …

Sequence-selective recognition of DNA duplexes is important for a wide range of
applications including regulating gene expression, drug development, and genome editing …

Bacterial adaptation is largely shaped by horizontal gene transfer, xenogeneic silencing
mediated by lineage-specific DNA bridgers (H-NS, Lsr2, MvaT and Rok), and various anti …

Significant heat capacity changes (ΔC p) often accompany protein unfolding, protein
binding, and specific DNA-ligand binding reactions. Such changes are widely used to …

The molecular structure of the DNA A‐tract dodecamer d (CGCAAATTTGCG) complexed
with the drug Hoechst 33258 has been determined by X‐ray diffraction analysis. The …

Develo** a molecular view of the thermodynamics of DNA recognition is essential to the
design of ligands for regulating gene expression. In a first comprehensive attempt at …

The viability of using thiazole orange as an alternative to ethidium bromide in a fluorescent
intercalator displacement (FID) assay is explored by profiling the DNA binding affinity and …