Standardization of Synthetic Biology Tools and Assembly Methods for Saccharomyces cerevisiae and Emerging Yeast Species

K Malcı, E Watts, TM Roberts, JY Auxillos… - ACS synthetic …, 2022 - ACS Publications
As redesigning organisms using engineering principles is one of the purposes of synthetic
biology (SynBio), the standardization of experimental methods and DNA parts is becoming …

Gene silencing in plants using artificial microRNAs and other small RNAs

S Ossowski, R Schwab, D Weigel - The Plant Journal, 2008 - Wiley Online Library
Comprehensive analysis of gene function requires the detailed examination of mutant
alleles. In Arabidopsis thaliana, large collections of sequence‐indexed insertion and …

A microbial supply chain for production of the anti-cancer drug vinblastine

J Zhang, LG Hansen, O Gudich, K Viehrig… - Nature, 2022 - nature.com
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary
metabolites with many medicinal properties, including the essential anti-cancer therapeutics …

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response

Y Takahashi, J Zhang, PK Hsu, PHO Ceciliato… - Nature …, 2020 - nature.com
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and
abscisic acid (ABA) signal transduction network. The core ABA signalling components are …

Multi-Knock—a multi-targeted genome-scale CRISPR toolbox to overcome functional redundancy in plants

Y Hu, P Patra, O Pisanty, A Shafir, ZM Belew… - Nature plants, 2023 - nature.com
Plant genomes are characterized by large and complex gene families that often result in
similar and partially overlap** functions. This genetic redundancy severely hampers …

An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis

L Arribas-Hernández, S Bressendorff… - The Plant …, 2018 - academic.oup.com
Methylation of N6-adenosine (m6A) in mRNA is an important posttranscriptional gene
regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins …

The Standard European Vector Architecture (SEVA): a coherent platform for the analysis and deployment of complex prokaryotic phenotypes

R Silva-Rocha, E Martínez-García, B Calles… - Nucleic acids …, 2013 - academic.oup.com
Abstract The 'Standard European Vector Architecture'database (SEVA-DB, http://seva. cnb.
csic. es) was conceived as a user-friendly, web-based resource and a material clone …

The seco-iridoid pathway from Catharanthus roseus

K Miettinen, L Dong, N Navrot, T Schneider… - Nature …, 2014 - nature.com
The (seco) iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form
two large families of plant-derived bioactive compounds with a wide spectrum of high-value …

A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity

X Yu, Y **e, D Luo, H Liu, MVV de Oliveira, P Qi, SI Kim… - Cell, 2023 - cell.com
Enabling and constraining immune activation is of fundamental importance in maintaining
cellular homeostasis. Depleting BAK1 and SERK4, the co-receptors of multiple pattern …

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast

SA Bradley, BJ Lehka, FG Hansson… - Nature Chemical …, 2023 - nature.com
Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with
marketed pharmaceutical activities against a wide range of indications, including cancer …