Senescence and aging: the critical roles of p53
Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
Metabolic regulation by p53 family members
The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …
Master regulatory role of p63 in epidermal development and disease
E Soares, H Zhou - Cellular and Molecular Life Sciences, 2018 - Springer
The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …
[HTML][HTML] Control of metabolism by p53–cancer and beyond
Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …
development of most human cancers. However, the activation of p53 in response to stress …
The hypothalamus for whole-body physiology: from metabolism to aging
Obesity and aging are two important epidemic factors for metabolic syndrome and many
other health issues, which contribute to devastating diseases such as cardiovascular …
other health issues, which contribute to devastating diseases such as cardiovascular …
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation
G Zhou, J Wang, M Zhao, TX **e, N Tanaka, D Sano… - Molecular cell, 2014 - cell.com
Many mutant p53 proteins (mutp53s) exert oncogenic gain-of-function (GOF) properties, but
the mechanisms mediating these functions remain poorly defined. We show here that GOF …
the mechanisms mediating these functions remain poorly defined. We show here that GOF …
Molecular mechanisms of p63-mediated squamous cancer pathogenesis
MA Moses, AL George, N Sakakibara… - International journal of …, 2019 - mdpi.com
The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …
Emerging roles of p53 family members in glucose metabolism
Y Itahana, K Itahana - International journal of molecular sciences, 2018 - mdpi.com
Glucose is the key source for most organisms to provide energy, as well as the key source
for metabolites to generate building blocks in cells. The deregulation of glucose …
for metabolites to generate building blocks in cells. The deregulation of glucose …
Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts
The neural stem cell niche is a key regulator participating in the maintenance, regeneration,
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis
The role of p63 in cancer has been an area of intense debate and controversy. Is TP63
(which encodes p63) a tumour suppressor gene or an oncogene? This debate is partly due …
(which encodes p63) a tumour suppressor gene or an oncogene? This debate is partly due …