The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

J Wang, L Chen, P Qiang - Cancer cell international, 2021 - Springer
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …

The roles of insulin‐like growth factor 2 mRNA‐binding protein 2 in cancer and cancer stem cells

J Cao, Q Mu, H Huang - Stem cells international, 2018 - Wiley Online Library
RNA‐binding proteins (RBPs) mediate the localization, stability, and translation of the target
transcripts and fine‐tune the physiological functions of the proteins encoded. The insulin …

[HTML][HTML] Genetics of type 2 diabetes

O Ali - World journal of diabetes, 2013 - ncbi.nlm.nih.gov
Abstract Type 2 diabetes (T2D) is the result of interaction between environmental factors and
a strong hereditary component. We review the heritability of T2D as well as the history of …

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine

GC Mannino, F Andreozzi… - … /metabolism research and …, 2019 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Potential role of insulin growth-factor-binding protein 2 as therapeutic target for obesity-related insulin resistance

H Boughanem, EM Yubero-Serrano… - International journal of …, 2021 - mdpi.com
Evidence from observational and in vitro studies suggests that insulin growth-factor-binding
protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as …

Insulin-like growth factor 2 mRNA-binding protein 2—A potential link between type 2 diabetes mellitus and cancer

J Cao, W Yan, X Ma, H Huang… - The journal of clinical …, 2021 - academic.oup.com
Context Type 2 diabetes mellitus (T2DM) and cancer share a variety of risk factors and
pathophysiological features. It is becoming increasingly accepted that the 2 diseases are …

Type 2 diabetes-associated genetic polymorphisms as potential disease predictors

BZ Witka, DJ Oktaviani, M Marcellino… - … syndrome and obesity …, 2019 - Taylor & Francis
Diabetes is a major cause of mortality worldwide. There are several types of diabetes, with
type 2 diabetes mellitus (T2DM) being the most common. Many factors, including …

Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 …

S Huang, Z Wu, Y Cheng, W Wei… - Acta biochimica et …, 2019 - academic.oup.com
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP
protein family consisting of IGF2BP1~ 3 with the capacity of binding to many transcripts and …

Nutrigenomics in regulating the expression of genes related to type 2 diabetes mellitus

K Felisbino, JG Granzotti, L Bello-Santos… - Frontiers in …, 2021 - frontiersin.org
Nutrigenomics is the study of the gene-nutrient interaction and it indicates that some
nutrients, called bioactive compounds, can mold the genetic expression or change the …