Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

The blood–brain barrier (BBB) is the monocellular interface that divides the peripheral
circulation from direct contact with the central nervous system (CNS). This interface consists …

Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about
passage. Here, we used multiple-time regression analysis to examine the ability of 10 …

Statins have been prescribed extensively for their cholesterol-lowering properties and
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …

Adhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte
trafficking into the central nervous system. Using a lipid raft-based proteomic approach, we …

Background and purpose Alzheimer's disease (AD) is a common neurodegenerative
disease characterized by a neuroinflammatory state, and to date, there is no cure and its …

J. Greenwood, SJ Heasman, JI Alvarez, A. Prat, R. Lyck and B. Engelhardt (2011)
Neuropathology and Applied Neurobiology37, 24–39 Leucocyte–endothelial cell crosstalk …

Ischemic tolerance describes the adaptive biological response of cells and organs that is
initiated by preconditioning (ie, exposure to stressor of mild severity) and the associated …

Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the
therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological …

Understanding the mechanisms of leukocyte trafficking into the brain might provide insights
into how to modulate pathologic immune responses or enhance host protective mechanisms …