Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Deposition of tau protein aggregates in the brain of affected individuals is a defining feature
of “tauopathies,” including Alzheimer's disease. Studies of human brain tissue and various …

Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …

Background Tauopathies are neurodegenerative diseases that are associated with the
pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair …

Pathogenic α-synuclein and tau are critical drivers of neurodegeneration, and their
mutations cause neuronal loss in patients. Whether the underlying preferential neuronal …

Sustained imbalance in intracellular calcium (Ca2+) entry and clearance alters cellular
integrity, ultimately leading to cellular homeostasis disequilibrium and cell death …

The conversion and transmission of misfolded proteins established the basis for the prion
concept. Neurodegenerative diseases are considered “prion-like” disorders that lack …

Neurodegenerative tauopathies, including Alzheimer's disease, are pathologically defined
by the presence of aggregated forms of tau protein in brains of affected individuals. Previous …

Aggregation of the tau protein is thought to be responsible for the neurodegeneration and
subsequent functional impairments in diseases that are collectively named tauopathies …