Antimicrobial resistance is now considered a major global challenge; compromising medical
advancements and our ability to treat infectious disease. Increased antimicrobial resistance …

Cationic compounds are promising candidates for development of antimicrobial agents.
Positive charges attached to surfaces, particles, polymers, peptides or bilayers have been …

Amphiphilic cationic polynorbornene derivatives, soluble in water, were prepared from
modular norbornene monomers, with a wide range of molecular weights (M n= 1600− 137 …

To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism
(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene …

Infectious diseases continue to threaten human and animal health and welfare globally,
impacting millions of lives and causing substantial economic loss. The use of antibacterials …

Infected wounds are still one of the great challenges in medicine. In the last decade, it has
become increasingly clear that antimicrobial chemotherapy is limited by the spread of …

Infectious disease is a critically important global healthcare issue. In the US alone there are
2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile.
The physicochemical action on the bacterial envelope prevents or impedes the development …

Background: Negative-pressure wound therapy with instillation is increasingly utilized as an
adjunct therapy for a wide variety of wounds. Despite its growing popularity, there is a …