Interactions between microtubules and actin are a basic phenomenon that underlies many
fundamental processes in which dynamic cellular asymmetries need to be established and …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …

A crucial aim upon completion of whole genome sequences is the functional analysis of all
predicted genes. We have applied a high-throughput RNA-interference (RNAi) screen of …

The mechanism underlying cytokinesis, the final step in cell division, remains one of the
major unsolved questions in basic cell biology. Thanks to advances in functional genomics …

Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all
eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing …

In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …

Cell division ends with the physical separation of the two daughter cells, a process known as
cytokinesis. This final event ensures that nuclear and cytoplasmic contents are accurately …

In creating the mitotic spindle and the contractile ring, natural selection has engineered
fascinating precision machines whose movements depend upon forces generated by …

Cell migration occurs through the protrusion of the actin-enriched lamella. Here, we
investigated the effects of RNAi depletion of∼ 90 proteins implicated in actin function on …