Background Alternative splicing (AS), a posttranscriptional process, contributes to the
complexity of transcripts from a limited number of genes in a genome, and AS is considered …

Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …

Nucleic acids are constantly exposed to external agents that can induce chemical and
photochemical damage. In spite of the great advances achieved in the last years, some …

The pyrimidine–pyrimidone (6–4) photoproduct (64-PP) is an important photoinduced DNA
lesion constituting a mutational signature for melanoma. The structural impact of 64-PP on …

DNA is the target of chemical compounds (drugs, pollutants, photosensitizers, etc.), which
bind through non-covalent interactions. Depending on their structure and their chemical …

Objectives: The study was aimed to assess γ‑glutamyltransferase (GGT) activity and
concentration as a marker of oxidative stress induced by exposure to tobacco smoke in …

Rad4/XPC recognizes diverse DNA lesions to initiate nucleotide excision repair (NER).
However, NER propensities among lesions vary widely and repair-resistant lesions are …

We report a structural polymorphism of the S-DNA when a canonical B-DNA is stretched
under different pulling protocols and provide a fundamental molecular understanding of the …

The behavior of the structural parameters of DNA considering different levels of methylation
in CpG islands is studied by means of full-atom molecular dynamics simulations and …

Marine bacterium Rhodococcus sp. NJ-530 has developed several ultraviolet (UV) adaptive
characteristics for survival and growth in extreme Antarctic environment. Rhodococcus sp …